2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Cytotoxin

ADC Payload

ADC Cytotoxin

Related Products

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ADC cytotoxins (also known as payloads) are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a cytotoxin. The cytotoxin is the most important component as it determines the potency to kill cancer cells of an ADC.

There are many cytotoxins which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors. Except for the listed cytotoxins, there are numbers of traditional cytotoxic agents with similar mechanisms of killing cancer cells and can also be used in the development of ADCs.

ADC Cytotoxin Isoform Specific Products:

ADC Cytotoxin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-122534
    Mensacarcin
    Mensacarcin, a highly complex polyketide, strongly inhibits cell growth universally in cancer cell lines and potently induces apoptosis in melanoma cells. Mensacarcin targets to mitochondria, affects energy metabolism in mitochondria, and activates caspase-dependent apoptotic pathways. Mensacarcin, an antibiotic, can be used as a cytotoxic component of antibody-drug conjugates (ADCs).
    Mensacarcin
  • HY-130959
    Tubulysin IM-2
    Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.
    Tubulysin IM-2
  • HY-159576
    O-Me Eribulin
    O-Me Eribulin is a derivative of Eribulin and is an ADC cytotoxin that can be used for ADC synthesis. O-Me Eribulin can inhibit the cell viability of SKBR3, MDA-MB-468, and A549 cells, with IC50 values of 0.2052, 0.1827, and 0.5151 nM, respectively. O-Me Eribulin can be used for tumor research.
    O-Me Eribulin
  • HY-77572R
    7-Epi 10-desacetyl paclitaxel (Standard)
    7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM.
    7-Epi 10-desacetyl paclitaxel (Standard)
  • HY-145397A
    (R)-(4-NH2)-Exatecan
    (R)-(4-NH2)-Exatecan is the R enantiomer of (4-NH2)-Exatecan (Compound A). (R)-(4-NH2)-Exatecan, a topoisomerase inhibitor, is a derivative of Exatecan. (R)-(4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs).
    (R)-(4-NH2)-Exatecan
  • HY-173070
    TLR7 agonist 29
    TLR7 agonist 29 (Compound 1) is the agonist for TLR7 with an EC50 of 5.2 nM for human TLR7 (EC50 for mouse TLR7 is 48.2 nM). TLR7 agonist 29 activates bone marrow-derived macrophages (BMDMs), stimulates myeloid cells in the tumor microenvironment, promotes the expression of PD-L1, CD86 and IFN-α. TLR7 agonist 29 can be used as payload for synthesis of ADC.
    TLR7 agonist 29
  • HY-130995
    Agrochelin
    Agrochelin, an alkaloid cytotoxic antibiotic, is produced by the fermentation of a marine Agrobacterium sp. Agrochelin has cytotoxic activity in tumor cell lines.
    Agrochelin
  • HY-156796
    Akt/ROCK-IN-1
    Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. Akt/ROCK-IN-1 has antitumor activity for neuroblastoma.
    Akt/ROCK-IN-1
  • HY-P990894
    Anti-DM1 antibody(14E3) (Rabbit mAb)
    		Control
    Anti-DM1 antibody (14E3) (Rabbit mAb) is a rabbit-derived IgG type antibody, targeting to DM1 (HY-19792). Anti-DM1 antibody (14E3) (Rabbit mAb) can be used for ELISA experiment in species independent background.
    Anti-DM1 antibody(14E3) (Rabbit mAb)
  • HY-133571A
    Aminohexylgeldanamycin hydrochloride
    Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities.
    Aminohexylgeldanamycin hydrochloride
  • HY-150074A
    STING agonist-18 diTFA
    STING agonist-18 diTFA (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate.
    STING agonist-18 diTFA
  • HY-135901
    Py-MPB-amino-C3-PBD
    Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity.
    Py-MPB-amino-C3-PBD
  • HY-131058
    Muscotoxin A
    Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death.
    Muscotoxin A
  • HY-126678
    Dimethyl-SGD-1882
    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication.
    Dimethyl-SGD-1882
  • HY-132180
    Seco-DUBA hydrochloride
    Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.
    Seco-DUBA hydrochloride
  • HY-13631AS1
    Exatecan-d3 mesylate
    Exatecan-d3 (DX8951f-d3) mesylate is deuterium-labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL.
    Exatecan-d<sub>3</sub> mesylate
  • HY-148819
    NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
    		98.71%
    NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) is a topoisomerase I inhibitor，which can be delivered to cells through conjugated antibody targeting，and has good ADC activity in vivo and in vitro.
    NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
  • HY-126142
    Top1 inhibitor 1
    Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM.
    Top1 inhibitor 1
  • HY-133537
    Hygrolidin
    Hygrolidin is a 16-membered macrolide antibiotic produced by Streptomyces hygroscopicus D-1166. Hygrolidin has anti-fungus activity against Valsa ceratosperma. Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. Hygrolidin has antitumor activity.
    Hygrolidin
  • HY-160598
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45) is a camptothecin compound that can inhibit cell proliferation, with an IC50 of 2.92 ng/mL for MDA‑MB‑468 cells. Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol can be used for the research of cancer.
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol
Cat. No. Product Name / Synonyms Application Reactivity
ADC Cytotoxin Isoform Comparison

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